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[MacOSX] Monolix Suite 2016R1

on 15 January 2016
Total Files1
Size159.46 MB
Create Date15 January 2016
Last Updated13 May 2016


Architecture: 64 bits
Operating system: MacOSX

Possible troubleshooting
When downloading the package, or launching the installer, the antivirus may tell that the executable file is risky, considered malicious and stopped working. This is due to the fact that MonolixSuite embeds a compiler for the Mlxtran language. Thus, the antivirus put it in quarantine or remove it.  Two solutions are available:
1/ Deactivate your antivirus auto-protection process during download and installation, or
2/ Restore the file from the quarantine.
To know more, please see the following link.

- install and launch   at least once Xcode, in order to being able to compile any C++ code  on your computer.
- install  XQuartz (or X11 for osX < 10.7), close and restart your session at least once after the installation, in order to make the  system  recognize the path of X11.
These  operations must be done after any update or upgrade of your system.  XQuartz can be founded on Apple's website, Xcode can be installed  using  App

Matlab is not necessary to run this version of the software, a stand alone version of Monolix is provided. However, the user can use its own Matlab to run Monolix. In that case, supported Matlab version are between Matlab2010bSP1 and Matlab2015a.
perl is required to run perlScripts and the validation suite; it is not required otherwise.

For using the calculation engine Simulx, the user can not access directly to it as no user interface is provided, yet. Thus, the user should have R (version greater than 3.2 is recommended) and download the R-package mlxR (see here) to use the calculation engine Simulx.

About the installer 

Double click on monolixsuite2016R1-installer.dmg an installer (with an installation icon) will be available, double click on the installer and follow instructions.

Warning: you could have a  security warning of your computer which refuses to install a software downloaded from the net by an unidentified    developer: go to the system preferences  panel of your computer->security an click on "authorize the installation of monolixsuite2016R1"

Licence and activation 
Mlxplore, Monolix and Simulx require an activation key. Please go to the download page if you do not have your license key yet. The licence activation procedure can be seen also on the download page at the licence activation section.

The user can also go to <InstallationMenu MonolixSuite2016R1>/Lixoft/MonolixSuite2016R1/bin to access to Datxplore, Mlxplore, and Monolix.

For the calculation engine Simulx, the user should access it through R.

User guides

The data set, the Mlxtran syntax and each software has a on-line documentation on indepedant websites

  • Data set guide here
  • Mlxtran guide here
  • Datxplore guide here
  • Mlxplore guide here
  • Monolix guide here
  • Simulx guide using mlxR R-package here

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Jonathan CHAUVIN[MacOSX] Monolix Suite 2016R1