<MODEL>
[LONGITUDINAL]
input = {k, ka, V, WEIGHT}

PK: 
compartment(cmt=1, amount=A1, concentration=Cc1, volume=V)
absorption(cmt=1, type=1, ka, p=WEIGHT)
elimination(cmt=1, k)

compartment(cmt=2, amount=A2, concentration=Cc2, volume=V)
absorption(cmt=2, type=2, ka, p=1)
elimination(cmt=2, k)

EQUATION:
ddt_A1= 0
ddt_A2= 0

[INDIVIDUAL]
input={V_pop, omega_V, beta, WEIGHT}

EQUATION:
lw = log(WEIGHT/70)

DEFINITION: 
V = {distribution=logNormal, typical=V_pop, coefficient=beta, covariate=lw, sd=omega_V}

[COVARIATE]
input={weight_pop, omega_weight}

DEFINITION: 
WEIGHT =  {distribution=normal, typical=weight_pop, sd=omega_weight}


<DESIGN>
[ADMINISTRATION]
adm_mg_kg = {time=5, amount=1, type=1}
adm_mg = {time=5, amount=70, type=2}

<PARAMETER>
V_pop = 10
omega_V = .2
beta = 1
k = .4
ka = 1
weight_pop = 70
omega_weight = 15


<OUTPUT>
grid = 0:.01:30
list = {Cc1, Cc2}

<RESULTS>
[GRAPHICS]
fig1 = {y={Cc1}, ylabel='Concentration with weight proportional administration', xlabel = 'Time'}
fig2 = {y={Cc2}, ylabel='Concentration with constant administration', xlabel = 'Time'}

<SETTINGS>
[GRAPHICS]
nb_simulation = 200
iiv_parameter = true
iiv_covariate = true