TMDD workshop
Lixoft and Gilbert Koch are running a 1 day hands-on workshop on Target Mediated Drug Disposition models with the MonolixSuite on Monday the 5 th of June
The workshop is intended to pharmacometricians wishing to have an introduction and an overview of TMDD. No prior experience of the MonolixSuite nor population PK modeling of biologics is required. It will provide an overview of the characteristics of the PK of therapeutic proteins, introduce TMDD modeling concepts (equations, approximations, underlying assumptions), and discuss guidelines for the development of TMDD models. Hands-on lectures to explore the behavior of TMDD models, as well as to model step by step a TMDD PK data set, will be included.
Agenda:
[AM] TMDD concepts:
- Introduction to the PK of therapeutic proteins
- Introduction to TMDD modeling concepts, presentation of the system of equations, usual approximations and their underlying assumptions
- Hands-on: exploration of the characteristics of the main TMDD models using Mlxplore
- Guidelines for the choice of a TMDD model depending on the available data, discussion of identifiability issues
[PM] Applications
- Hands-on: development of a TMDD model on a PK data set
- Advanced cases: TMDD with drug-drug interaction, e.g. to describe endogenous / exogenous scenarios
Instructors
Dr Géraldine Ayral is a multidisciplinary scientist with a main interest in pharmacometrics. |
Gilbert Koch, PhD, is a multidisciplinary scientist in the area of pharmacokinetics (PK) and pharmacodynamics (PD) modeling. |
Price per person
Industry: 600€ – Academy: 300€ – Student: 150€
+ 100€ if registration after May 4th, 2017
Location
Hotel Mercure Budapest Buda
Krisztina Körút 41-43
1013 Budapest
Hungary
Registration