TMDD workshop

Lixoft is running a 1 day hands-on workshop on Target Mediated Drug Disposition models with the MonolixSuite on Thursday the 3rd of October. The workshop is intended to pharmacometricians wishing to have an introduction and an overview of TMDD. No prior experience of the MonolixSuite nor population PK modeling of biologics is required. It will provide an overview of the characteristics of the PK of therapeutic proteins, introduce TMDD modeling concepts (equations, approximations, underlying assumptions), and discuss guidelines for the development of TMDD models. Hands-on lectures to explore the behavior of TMDD models, as well as to model step by step a TMDD PK data set, will be included.

Agenda:

[AM] TMDD concepts:

• Introduction to the PK of therapeutic proteins
• Introduction to TMDD modeling concepts, presentation of the system of equations, usual approximations and their underlying assumptions
• Hands-on: exploration of the characteristics of the main TMDD models using Mlxplore
• Guidelines for the choice of a TMDD model depending on the available data, discussion of identifiability issues

[PM] Applications

• Hands-on: development of a TMDD model on a PK data set
• Advanced cases: TMDD with varying target, …

Instructor

Dr Pauline Traynard joined Lixoft in 2017 as Applications Manager. She has a multidisciplinary background focusing on computational and systems biology. After a double engineering degree specializing in computational biology from Ecole Polytechnique and MINES ParisTech (Paris, France) obtained in 2012, she applied different mathematical formalisms to model biological rhythms as part of her PhD studies at INRIA and IBENS Paris, and prostate cancer as a postdoctoral fellow in Institut Curie.

Price per person

Industry: $600 – Academia and non-profit: $300
The prices are VAT exempted, it should be added if applicable.

Location

Courtyard by Marriott Boston-Cambridge
777 Memorial Drive, Cambridge, MA  02139