MonolixSuite workshop

Lixoft is running a 1 day hands-on workshop on the Monolix Suite on Thursday the 24th of October.
The course is designed for modelers with none to intermediate knowledge of the MonolixSuite. It will present the full modeling and simulation workflow on concrete examples using the 4 applications of the suite: Datxplore for the data visualization, Mlxplore for the exploration of the model behavior, Monolix for parameter estimation and model diagnosis and Simulx for clinical trial simulations.
The course will in particular focus on the modeling strategy, the model implementation and the model diagnosis. Two real case studies will be used, covering a PK and a PKPD example of modeling and simulation.

Agenda:

[AM] Introduction to the MonolixSuite:

• Introduction of the different applications
• Data exploration using Datxplore
• Parameter estimation and model diagnostic using Monolix
  • Model definition using the library, the macros or ODEs
  • Description of the several tasks/algorithms
  • Model diagnostic and improvement using the graphics
• Model exploration using Mlxplore
• Simulations for a priori dose finding using Simulx
  • Overview of simulx features
  • Toxicity and target attainment of the usual treatment
  • Treatment individualization using covariates or real-time drug monitoring

[PM] Hands-on: modeling and simulation of a PKPD data set

• Data exploration using Datxplore
  • Detecting outliers
  • Getting ideas for the structural model
• PK-PD modeling in Monolix
  • Mlxtran coding
  • Monolix graphical results visualization: Convergence, Diagnostic plots / Predictive checks, Model assessment
• Model exploration using Mlxplore
  • Mlxtran coding and export of projects from Monolix to Mlxplore
  • Exploration of the model behavior
• Clinical trial simulations using Simulx

Main instructor

Dr Monika Twarogowska joined Lixoft in 2019 as Applications Manager. She has multidisciplinary knowledge, confirmed by a double master degree – in Applied Physics (Gdańsk University of Technology, Poland) and in Mathematical Engineering (University of L’Aquila, Italy) – and Ph.D in Applied Mathematics (University of L’Aquila, Italy), and academic research experience in mathematical modelling in biology, simulations and programming gained in Inria-Sophia Antipolis, Ens-Lyon and CNR-Rome. Her results are focused, on one side, on modelling biological phenomena ranging from formation of stem cells clusters and tumour growth to intracellular movements of molecules and gene expression patterns, and on the other side, on quantitative analysis and development of simulation tools.

Price per person

Industry: $600 – Academia (not from University of Florida): $300 – University of Florida: free
The prices are VAT exempted, it should be added if applicable.

Location

University of Florida, Research and Academic Center at Lake Nona
Center for Pharmacometrics and Systems Pharmacology
6550 Sanger Road.
Orlando, FL 32827-7400