From simple to complex simulations with Simulx

Tuesday 28 June 2022 – half-day morning

This training will give you the keys to confidently set up simulation scenarios and efficiently answer “what if” questions using Simulx – a simulation tool equipped with a user-friendly graphical interface and fully integrated with all MonolixSuite applications.
During this workshop, we will teach you how to use the Simulx interface and define typical simulation workflows, starting either from scratch or from a Monolix run. This will include the definition of simulation elements, exploration and construction of a study design, simulation of clinical trials and endpoints. The workshop will alternate lectures and interactive hands-on sessions, starting from simple treatments and going up to complex clinical trials.

Prior experience with Monolix is not mandatory but welcome. Participants are invited to also follow the workshop “Introductory course on pharmacometrics modeling with Monolix” on the previous day. Temporary licences for the MonolixSuite will be provided.

This is an in-person workshop taking place in Ljubljana (Slovenia), as a satellite event of the PAGE conference.

Agenda:

• Lecture/Demo:
  • presentation of the Simulx graphical user interface.
  • definition of simulations elements: model, parameters, treatment, and outputs
  • interactive and real-time model exploration
  • setup of Monte-Carlo simulations
  • simulation output post-processing via outcomes and endpoints
  • use of Simulx via the lixoftConnectors R package
• Hands-on:
  • Resimulate a Monolix project
  • Compare two treatments
  • Simulation on a specific population
  • Covariate-dependent treatment
  • Clinical trial design investigation

Main instructor

Dr Monika Twarogowska joined Lixoft in 2019 as Applications Manager. She has multidisciplinary knowledge, confirmed by a double master degree – in Applied Physics (Gdańsk University of Technology, Poland) and in Mathematical Engineering (University of L’Aquila, Italy) – and Ph.D in Applied Mathematics (University of L’Aquila, Italy), and academic research experience in mathematical modelling in biology, simulations and programming gained in Inria-Sophia Antipolis, Ens-Lyon and CNR-Rome. Her results are focused, on one side, on modelling biological phenomena ranging from formation of stem cells clusters and tumour growth to intracellular movements of molecules and gene expression patterns, and on the other side, on quantitative analysis and development of simulation tools.

Price per person

Industry: 300€ – Academia: 150€
The prices are VAT exempted, it will be added if applicable.

Get a 50% discount on the second and third workshop you register to!

• Introductory course on pharmacometrics modeling with Monolix + From simple to complex simulations with Simulx + Non compartmental, bioequivalence and beyond with PKanalix: Industry: 900€ – Academia: 450€
• Introductory course on pharmacometrics modeling with Monolix + From simple to complex simulations with Simulx:
  Industry: 750€ – Academia: 375€

Location

Cankarjev Dom cultural and congress centre, Ljubljana, Slovenia (same venue as the conference).