MonolixSuite installation and administration guide

1.About the installer

Operating system specifics

Windows specifics

No prerequisite. However, it will install a version Microsoft Visual C++ 2015 redistribuable (it was installing a version 2012 for MonolixSuite2016R1)

Linux specifics

Make sure you have gcc/g++/make installed or install them.The gcc version should be at least a 4.8 version.
Notice that we can provide on request a silent installer for Linux operating system.

Mac OS X 10.6 or higher specifics

– install and launch at least once Xcode, in order to being able to compile any C++ code  on your computer.
– install XQuartz (or X11 for osX < 10.7), close and restart your session at least once after the installation, in order to make the  system  recognize the path of X11.
These  operations must be done after any update or upgrade of your system.  XQuartz can be founded on Apple’s website, Xcode can be installed  using  App


  • copy the installer on your Desktop or in a temporary directory,
  • double click on the executable and follow the instructions. The instructions are very simple and will allow you to define the installation folder, the shortcut menu name, …

Notice that the software should be installed in a directory without any special character in the path.

Additional folder created by MonolixSuite

When launching an application of MonolixSuite, a folder lixoft will be created in the user folder, i.e.
– C:\Users\UserName\lixoft for windows OS
– /home/UserName/lixoft for Linux OS
– /Users/UserName/lixoft for Mac OS
Two elements need to be noticed. First, the user must have the full permission on the lixoft folder. Indeed, we use this folder to add temporary files and compile the models. Secondly, we recommend to have no special character in the UserName to ensure smooth operation.


At the end of the installation, during the initialization, the license activation process occurs. It will check if you already have a license.
If you have a valid license, you will be able to run the software as the license is independent of the software version.
If not, a window will pop up requesting an activation key, or a licence file. If you do not have it, just click on the cross to cancel it. Two things have to be noticed:

  • If you do not have a valid license key, the software will be installed and you will be able to re-activate it later.
  • If your license key is valid for several software and/or for the MonolixSuite, the license request will be done for the first software and will automatically be validated for the other one.


If you have any trouble during the installation, see here or send an email to if you still have issues.

2.How to see that the applications are well installed ?

Here is for each application a simple procedure to be sure that everything is well installed


  1. Open Datxplore
  2. Go to the Demos (on the left) as on the following figure and load the pkRemifentanil data set
  3. Datxplore should load the project and display the observed data plot like on the following figure


  1. Open PKanalix
  2. Go to the Demos (on the left) and choose project_covariates in 1.basic examples
  3. The Tasks, Results and Plots tabs appear. By default, you are on the Tasks>NCA tab. Click on the button “NON COMPARTMENTAL ANALYSIS” to perform the calculation.
  4. After the calculation, you are redirected to Results>NCA>Indiv.Estim corresponding to the individual estimates of the NCA parameters. 
  5. You can now click on Plots and by default you’ll see the Individual NCA parameters with respect to the covariates.


  1. Open Monolix
  2. Go to the menu Demos and choose theophylline_project in section 1.1 libraries of models
  3. Monolix loads the project and the interface looks like the following figure 
  4. Clicking on the “Run” button launches the scenario as on the following figure
  5. Close the scenario using the close button and the graphics are displayed behind on the Individual fits plot


  1. Open Simulx
  2. Go to the menu Demos and choose importFromMonnolix_compareTreatments in section 1.overview

  1. Simulx loads the project and the interface looks like the following figure
  2. Go on the Simulation tab where the simulation is defined as shown here and click on RUN
  3. The numerical results of the simulations are the displayed
  4. By clicking on the Plots tab, you can see the numerical results as here.


Downloading MonolixSuite

Problem: My web browser claims that the Monolix download website has insufficient reputation and suggests to stop the download.
Solution: Some browsers like Google Chrome and Internet Explorer may ask whether to keep or remove the MonolixSuite archive just after download because of the insufficient reputation of the Lixoft website, simply because it is insufficiently referenced. Please ignore the warning and choose to keep the file. You can use a MD5 tool to verify that the downloaded file is not corrupted.

Problem: The MonolixSuite archive is removed just after being downloaded.
Solution: Some antivirus may consider the MonolixSuite archive as risky and put it in quarantine or remove it. This is due to the fact that MonolixSuite embeds a compiler for the Mlxtran language. Two solutions are available:

  1. Deactivate your antivirus auto-protection process during download and installation, or
  2. Restore the file from the quarantine.

To restore the file from quarantine, please refer to the documentation of your antivirus software. For the most common examples:

  • Norton Antivirus: In the Norton product main window, double-click Security, and then click History, then Quarantine as explained here.
  • Avast Antivirus: Open Avast, Choose Maintenance, then Virus Chest as explained here.
  • Mcafee Antivirus: Click Navigation (or click the cog at the top right), and click Quarantined and Trusted Items as explained here.

You should see the downloaded file among the quarantined files. Execute the Restore action; the archive will be restored into the directory used for downloading. Click on the archive (ignore a possible “malware” warning, again related to the fact that MonolixSuite embers a compiler.), and installation will start.

Installing MonolixSuite

Problem: When launching the installer, my antivirus tells me that the executable file stopped working.
Solution: If your antivirus apparently stopped the execution, it is  just scanning the installation program. Thus, just “Close the program” and the installer will reopen automatically.

Running an application of MonolixSuite

Problem: When launching the standalone version, my antivirus tells me that some executable file is risky.
Solution: If your antivirus apparently removed an executable file, check if it was actually put on Quarantine, or removed. If it is in Quarantine, please restore it by following the same instructions as provided above. If the file was removed you will need to reinstall MonolixSuite. You should be able to add this file to your antivirus Trusted Zone or Trusted files.
In addition, you can define it in the trusted zone and thus not scan this folder.

4.Floating licence management using RLM

The use of a floating license requires to set up a license server. We provide here the way to do it by your local IT. Notice that we also provide this as a cloud-based service. Please contact to know more on this cloud based service.

System requirements

  • The license server should be installed on a real machine, not on a virtual machine.
  • The machine hosting the license server should be a 64 bits machine
  • Other applications can be installed on the machine hosting the license server

Downloading and running the service

windows64Click on the icon above to download the license server. Unzip it and launch rlm.exe.

icon_lin64Click on the icon above to download the license server and launch ./rlm

The rlm server is delivered with an embedded Web Server to perform normal administration tasks. At this step there is no license available yet; the IT manager should use the web interface to download the license by following the procedure below.

License key activation


  • The activation process requires an internet connection. Else wise, the license has to be created by Lixoft. Send a mail to with the following informations (MAC ADDRESS and IP Address of the machine hosting the license server.
  • You do not need to be on the machine hosting the license manager to get the license, it could be done on any machine connected to this machine.
  • On the following steps, the license server should be started (rlm.exe in Windows or ./rlm in Linux).

0/ In the web browser, type IpAddress:wsp, where IpAddress is the IP address of the machine hosting the license server and wsp is the web server port (5054 by default) (e.g. Click on “Activate license” in the left bar.

and BEGIN License Activation:

1/ Select activation server: Enter the ISV activation website: And click on Next button.

2/ Specify license activation key. Fill the ISV input with the string “lixoft” (without the quotes) and the License activation key with the activation key provided by Lixoft (key format is xxxx-xxxx-xxxx-xxxx)

3/ specify machine for nodelocked license or license server and license count and click on the Next buttonNotice, the license count cannot exceed the number of bought licenses.

4/ Specify license file location and click on the Next button. By default, it is located next to the executable and the associated name is activated1.lic. If it already exists, it increments the number.

5/ verify parameters and request license. Click on REQUEST LICENSE.

6/ Requesting license from internet. The license is generated and you need to restart the License server.

Frequent Asked Questions

  • Activation key already used. Notice that if you request too many license, the following message will appear
    Error generating License: -1005
    Activation key already used
    Attempting to access license generator at:

    you can not request more license that you have purchased.

  • Access issue. It means that you can not access to our server to get the license. Please check your internet connection and/or your firewalls.
    Error generating License: -132
    Cannot connect to specified URL (-132)
    Attempting to access license generator at:
    You were unable to connect to the URL you specified ( Please make sure that this system is able to access the internet site and try again.

License server management

The documentation of the management of the RLM server provided by Reprise Software is available in the following links

License server management startup options

rlm startup options

usage: rlm [-c <lic file path>] 
           [-dlog [+]<debug log path>] [-info] [-l] [-noudp]
           [-nows | -ws <port>] [-x [rlmdown|rlmremove]] [-v]
           [-install_service] [-delete_service] [-service_name <service name>]
           [-display_name <service display name>]
           [-user <service user name> -password <service password>]
           [-isv_startup_delay <ISV server startup delay>]
  • The -c license_file option specifies which license file to use. Notice that
    • This option overrides the setting of the RLM_LICENSE environment variable.
    • The license_file parameter can be a directory containing license files, all of which will be processed.
    • If no license file is provided, rlm will look in the folder where it is installed.
  • The -dlog logfile specifies the pathname for the server debug log. If logfile is preceded by the ‘+’ character, the logfile will be appended, otherwise it is overwritten.
  • The -info option causes RLM to print information about all copies of rlm that are running on this
    computer, including copies which have run in the prior 24 hours, then exit.
  • The -l switch causes rlm to only process command-line utilities from the local host.
  • The -noudp option tells RLM to not bind the UDP port (5053) used for replying to broadcast messages from clients
  • The -nows and -ws port options control the operation of the embedded Web Server.
    • The -nows option instructs the rlm server to not start the embedded web server.
    • The -ws port option instructs the rlm server to use port as the port number for the web server.
  • The -x [rlmdown | rlmremove] option controls whether the rlmdown and/or rlmremove commands will be processed by the server. Specifying only -x will disable both commands. Specifying either command name after the -x will disable just that command.
  • The -v option causes RLM to print it’s version and exit.
  • The -install_service and –service_name sname options are used to run the rlm server as a service under windows.
  • Optionally a username and password of a user account under which you wish to run the service may be specified, via the -user and -password arguments.
  • The -isv_startup_delay seconds option specifies that when running as a Windows service, rlm should delay seconds seconds before starting up the ISV servers. If not specified, there is no delay

Specific installation on as a service is described in RLM License Administration Manual on page 15.

License Server Startup Processing

License servers use The License Environment to find their license file. In addition, any file whose name ends in .lic in the current directory when the rlm server is started (or when the rlmreread command is issued) is implicitly added to the end of the license file path. Finally, and file whose name ends in .lic in the directory where the rlm binary resides is added to the list of license files processed. (Note: license files in the isv server’s binary directory are not processed, only the rlm binary directory is searched.)
License servers ignore port@host specifications in the License Environment. Once the list of license files is created, the license servers process all the resulting license files. The rlm server starts all ISV servers in all license files, and the ISV servers process and support all licenses in all license files with valid hostids.
When the rlm server starts, it uses the port # from the first file with the hostname on which it is running. The rlm server will attempt to use all the port #s in all the license files. It must be able to bind the port # in the first file. Once this is done, it attempts to use the port number from each additional file, logging either success or failure in the debug log. This means that when you receive a new product or license file, it can be installed in the application and rlm server directories without changing the port number in that file, which simplifies license administration.
ISV servers process all licenses in all files that have a valid hostid (by this we mean a hostid that corresponds to the computer on which the license server is running). The ISV servers attempt to combine licenses whenever possible and when combined the license counts add to create a single pool of licenses.

License Server Administration

There are various administration commands that can be used to cause the license servers to reread their license files, to remove licenses from certain users, etc. For a description of these administration commands, see License Administration Tools on page 39. In addition, options can be specified for each ISV server in The ISV Options File. You can restrict access to administration commands via The RLM Options File.

Hostname, ports and firewall configuration

If for any reason, the server port or the server hostname is not registered in a DNS, it is possible to change these informations directly on licence file. The line HOST can be changed by HOST .

The license server opens three ports. These ports are as follows:

  • rlm web server port (default 5054) web browsers connect here. It is needed for manage the server through the interface.
  • rlm client connection port  (default 5053) this is the port that clients first connect to.  rlm redirects them to the ISV server client connection port
  • ISV server client connection port – clients connect here to check out licenses

Thus, if there is a firewall, the ports 5053, 5054 and the ISV port should be opened. These ports are configurable as could be seen in the following.

  • rlm web server port. If the web server port (5054) is not available you can launch license server with a new port by using the program option -ws (e.g: rlm -ws 5055). This port will be called the wsp in the following.
  • rlm client connection port (default 5053) this is the port that clients first connect to.  rlm redirects them to the ISV server client connection port. If the server port (5053) is not available, a file config.conf has to be created in the rlm directory and has to contain the following information: HOST {IP} {MAC ADDRESS} {NEW PORT} e.g. HOST a8c0f82e 5060
  • ISV server client connection port – clients connect here to check out licenses. The ISV port can be set directly in license file by changing the ISV line as follow:
    ISV lixoft port=

What to share that with the users?

Classical floating usage

For this usage, the IT should send the users the .lic file. In that case, the user can

  • Set it when opening an application when the application is requesting a license,
  • Put it in his {USER_NAME}/lixoft/license folder.

Cluster floating usage

See here.

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Jonathan CHAUVINMonolixSuite installation and administration guide