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[Win64] Monolix Suite 2019R2

on 11 October 2019

  • Version
  • 29113 Download
  • 141.35 MB File Size
  • 1 File Count
  • 11 October 2019 Create Date
  • 17 June 2020 Last Updated
  • Download


Note: As PKanalix is a fresh new product, a dedicated license is necessary. Thus if you already have a MonolixSuite license, you need to ask for a PKanalix license.

Minimum system requirements

  • Architecture: 64 bits
  • Operating system: Windows 7, Windows 8, Windows 10, Windows server 2012, Windows server 2016
  • 1GB RAM or above
  • Optimally standard screen resolution not less than 800x600 pixels is recommended.

Possible troubleshooting

Resolution and display

  • OpenGL technology impact on remote access: Monolix and Datxplore interface were updated with OpenGL technology. This implies that the remote access using direct rendering is not working with OpenGL. In that case, the OpenGL application sends instructions directly to the local hardware bypassing the target X server. This is only possible with single machine. We cannot use it in MonolixSuite with X11 forwarding. Thus, an indirect rendering should be used, i.e. the remote application sends instructions to the X server which transfers them to the graphics card. It is possible to do that with ssh application, but it needs a dedicated configuration depending on the machine and the operating system. Other application as VNC or Remina can be used for an indirect rendering.
  • If the graphical user interface appears with too high or too low resolution, follow these steps:
    • open Monolix
    • load any project from the demos
    • in the menu, go to Settings > Preferences and disable the "High dpi scaling" in the Options.
    • close Monolix
    • restart Monolix

cmd.exe not is path

If you get the following error message: Cannot find cmd.exe in current system path PATH, please follow the steps below to add C:Windowssystem32, which contains the cmd.exe executable, to the PATH.

  • from file browser, right click on Computer > Properties. You arrive in control panel > system and security > system.
  • click advanced system settings (on the left of the window)
  • click environment variables in the pop-up window
  • in the system variables, edit the Path variable:
  • add  C:Windowssystem32;  at the beginning
  • save and retry

Antivirus problem

When downloading the package, or launching the installer, the antivirus may tell that the executable file is risky, considered malicious and stopped working. This is due to the fact that MonolixSuite embeds a compiler for the Mlxtran language. Thus, the antivirus puts it in quarantine or removes it.  Two solutions are available:
1/ Deactivate your antivirus auto-protection process during download and installation, or
2/ Restore the file from the quarantine.
To know more, please see the following link.


For using the calculation engine Simulx, the user can not access directly to it as no user interface is provided, yet. Thus, the user should have R (with a version greater than 3.2 is recommended) and download the R-package mlxR (see here) to use the calculation engine Simulx.

About the installer

  • Copy the installer on your Desktop or in your windows temporary directory.
  • Double click on the executable and follow the instructions.
  • Icons for Datxplore, Mlxplore, and Monolix will appear on the desktop.

Licence and activation

Mlxplore, Monolix and Simulx require an activation key. Please go to the download page if you do not have your license key yet. The licence activation procedure can be seen also on the download page at the licence activation section.


Under Windows operating system, the icons for Datxplore, Mlxplore and Monolix are on the desktop and available through the start menu.

The user can also go to <InstallationMenu MonolixSuite2019R2>/bin (C:/ProgramData/Lixoft/MonlixSuite2019R2/bin by default) to access to the .bat for Datxplore, Mlxplore, and Monolix.

For the calculation engine Simulx, the user should access it through R.

To see if everything is well installed, you can see here.

User guides

The data set, the Mlxtran syntax and each software has on-line documentation.

  • Data set guide here
  • Mlxtran guide here
  • Datxplore guide here
  • PKanalix guide here
  • Mlxplore guide here
  • Monolix guide here
  • Simulx guide using mlxR R-package here


Jonathan CHAUVIN[Win64] Monolix Suite 2019R2